In the first half of this year,Raw material products independently developed by Seedling BiotechPatents related to Ectoine (also known as tetrahydro-pyrimidine) and boswellin"Construction method and application of a genetically engineered bacterium producing tetrahydro pyrimidine""Method and engineered bacteria for preparing (β,S) configuration bosin through enzyme catalysis"They passed the examination conducted by the State Intellectual Property Office in April and June respectively,was granted the patent right for invention.The acquisition of two invention patent certificates,It not only marks the official recognition of Seedling Biotechnology's innovative technological capabilities,It also further contributes to the company's intellectual property system,Protect the core technology of raw material products.Invention patent certificate for Ectoine and BosinRaw material product - EctoineEctoine (INCI name: tetrahydroxymethyl pyrimidine carboxylic acid) is a small-molecule amino acid derivative. It appears as white crystals or powder, and its molecular structure carries a carboxyl group and a cyclic amino group, which can form a strong electrostatic potential. This potential structures the free water within cells. Through its powerful water molecule complexing ability, it forms a hydration layer around biomolecules, protecting the structure and function of cells and biological macromolecules.In cosmetics, ectoine is often used as a skin conditioning agent, which can enhance skin's water-locking ability, provide long-lasting moisturization, alleviate damage and inflammation caused by external irritants such as dry environments, surfactants, and ultraviolet radiation, and strengthen the repair and immune capabilities of skin cells.With the continuous deepening of research on ectoine, it has also been discovered that ectoine has the effect of enhancing crop stress resistance, promoting crop growth, and strengthening crop resistance to pests and diseases in the agricultural field. Ectoine is expected to play a significant role in the improvement of saline-alkali soil, coping with extreme climate, and the transformation towards green agriculture.Through thorough research and meticulous design of the biosynthetic pathway of ectoine, Xi Zhenglin has constructed engineered bacterial strains capable of efficiently synthesizing ectoine and completed the upgrade of mass production processes. Leveraging the independently developed biosynthetic technology of ectoine, he has significantly expanded the range of available raw materials and significantly reduced the production cost of ectoine.Raw material product - BosinBoswellin (INCI Chinese name: hydroxypropyl tetrahydroxypyrantriol) is a functional ingredient commonly used in cosmetics. It can promote the synthesis of glycosaminoglycans in the human dermis, enhance the production of proteoglycans, and stimulate the regeneration of collagen. Glycosaminoglycans, proteoglycans, and collagen are all crucial structural components of the extracellular matrix, playing a pivotal role in maintaining the skin's firmness, uniformity, smoothness, and elasticity, as well as preserving its healthy state.The external manifestations of skin aging include skin thinning, skin sagging, loss of elasticity, and deepening wrinkles. In research on skin aging, it has been found that both naturally aged skin and photo-aged skin exhibit varying levels of decline in glycosaminoglycans and proteoglycans. The use of cosmetics containing boswellin can promote epidermal renewal, strengthen skin structure, firm the skin, improve wrinkles, increase skin radiance and elasticity. Therefore, boswellin is known as one of the "three anti-aging giants" in the skin care industry and is widely used in face creams, serums, and other products from prestigious brands.Boswellin is a β-xylose derivative with multiple chiral carbon atoms in its molecular structure. The spatial arrangement of chiral carbon atoms on its parent core is relatively fixed, while the carbon atom at position 7 in the aglycone (hydroxypropane) gives rise to two different configurations, namely (β,S) and (β,R), which are diastereoisomers. Studies have shown that the biological activity of the (β,S) configuration is superior to that of the (β,R) configuration, and the cytotoxicity of the (β,S) configuration is weaker than that of the (β,R) configuration.Boswellin is a β-xylose derivative with multiple chiral carbon atoms in its molecular structure. The spatial arrangement of chiral carbon atoms on its parent core is relatively fixed, while the carbon atom at position 7 in the aglycone (hydroxypropane) gives rise to two different configurations, namely (β,S) and (β,R), which are diastereoisomers. Studies have shown that the biological activity of the (β,S) configuration is superior to that of the (β,R) configuration, and the cytotoxicity of the (β,S) configuration is weaker than that of the (β,R) configuration.The biosynthetic technology of bosein developed by Xizhenglin Biotechnology utilizes specific biological enzyme catalysis, with acetone xyloside as the main raw material. It boasts advantages such as high substrate conversion rate and high product purity (purity of (β,S) bosein > 99%), and effectively achieves continuous production through immobilized enzyme technology.The raw materials of Xizhenglin Biotech, namely Ectoine and Boswellin, have currently obtained multiple third-party certifications such as safety assessment, quality inspection, and efficacy testing. With the innovative strength represented by patent certificates, they will provide strong endorsement for our customers in terminal product development and market application. As an innovative enterprise specializing in synthetic biology technology, Xizhenglin Biotech will continue to delve deeper in future development, realizing the vision of creating a better life with green technology.Safety assessment report on Ectoine and Boswellin raw materials  Quality test report of Ectoine and Boselium  Efficacy Test Report of Ectoine and BoswellinCore biological raw material productsIn recent years, relying on our self-developed core technology platform, our company has achieved significant breakthroughs in the fields of cosmetics, food, and health care product ingredients, successfully developing and mass-producing multiple innovative products. Leveraging our leading technological advantages and industrialization capabilities, we have provided high-quality, high-value-added ingredient solutions to customers worldwide. The following are our core featured products:Currently, these raw material products have been applied to the supply chains of over 20 leading enterprises across various industries, marking the maturity of the company's full-chain capabilities from "research and development to production and sales".Contact our Mr. Luo at 13588347582

The reprinted manuscript comes from the public account of Wuxi Jiante Pharmaceutical On March 9, 2022, Luo Maoxing, general manager of Zhejiang Xizhenglin Biotechnology Co., Ltd., and his party visited Wuxi Jiante Pharmaceutical for on-site inspection. Zhejiang Xizhenglin Biotechnology Co., Ltd. was established in Hangzhou in April 2021 (headquarters, set up its own factory), Wuxi as a branch (with its own independent research and development laboratory), backed by the south gate of Jiangnan University, has won thousands of awards from well-known institutions 10,000-level investment.The company has or will have a number of world-leading patented technologies. The company's main products include more than ten nutritional and health products such as prebiotics, silibinin, icariin, and curcumin. Nutrition product technology research and development, create its own research and development system, and strive to become a global technology leader in the nutrition and health industry.Sun Li, Marketing Director of Jiante Pharmaceutical, and the heads of relevant departments of the company received Mr. Luo and his party. And arranged staff to accompany Mr. Luo to visit the production workshop of Melatonin oral liquid, the production workshop of golden partner tablet, the exhibition hall of Jiante Pharmaceutical and other enterprise exhibition areas. Photo｜Visit the pavilion of "Youth Journey" Photo｜Visit the pavilion of "Youth Journey" Before leaving, representatives of both parties took a group photo in the company hall. And look forward to more learning and communication opportunities in the future, and deeper and wider cooperation in the future. Figure | Group photo

In a large number of researches and published papers on curcumin, many people will mention the relationship between curcumin and traditional Chinese medicine, and mention the example of Chinese people using traditional Chinese medicine turmeric to treat various diseases since ancient times.This paper covers the pharmacological effects of curcumin in many aspects: such as antioxidant, anti-inflammatory, anti-cancer and anti-cancer, neuroprotective such as anti-Alzheimer's disease and anti-autism in children, repair and protection of liver function, anti-virus such as anti-AIDS , anti-cardiovascular disease, anti-autoimmune disease, etc.In 2007, the most authoritative National Health Agency (NIH) in the United States approved curcumin for clinical trials against four diseases: rectal cancer, pancreatic cancer, senile dementia and multiple myeloma. Subsequently, clinical trials for various diseases such as breast cancer and osteoarthritis have also been approved for implementation.Curcumin, called Curcumin in English, is a yellow powder extracted from the tubers of the plant Curcuma longa. According to records, the common people of the Indian subcontinent have been consuming turmeric for 5,000 years.In China, turmeric is a commonly used traditional Chinese medicine. In the "Compendium of Materia Medica" by Li Shizhen of the Ming Dynasty, there is a detailed record of turmeric, saying that its medicinal properties are acrid, bitter, cold, and non-toxic. In addition to wind-heat and carbuncle swelling, turmeric is used in ancient recipes to treat arthralgia caused by rheumatism, and it can also treat unbearable heartache, and so on.What are the therapeutic effects of curcumin?Anti-inflammationCurcumin can treat inflammation that is not caused by bacteria and viruses. Rheumatoid arthritis, frozen shoulder and other diseases that the elderly often get, are inflammations that belong to this category.Inflammation is caused by some chemicals that can cause an inflammatory response to act on various parts of the body, such as prostaglandin (PG-E2), tumor necrosis factor (TNF) and so on. These harmful things are transformed from other chemical substances in the body. Take prostaglandins, for example, which are derived from a compound called arachidonic acid. This transformation must be catalyzed by an enzyme called cyclooxygenase (COX-2).In a large number of experiments, it was found that curcumin can effectively inhibit the activity of cyclooxygenase. Without the catalysis of cyclooxygenase, arachidonic acid cannot be converted into prostaglandins, thus blocking the production of inflammatory responses. This is one of the principles of curcumin's anti-inflammatory effect.The most effective anti-inflammatory drugs are steroid hormones such as cortisone and dexamethasone. But hormones suppress the human immune system and can cause great damage to multiple organs.Another useful class of drugs are non-steroidal anti-inflammatory drugs. We usually use it for antipyretic and analgesic, such as aspirin, ibuprofen, paracetamol, etc. But aspirin can aggravate gastrointestinal ulcers, and ibuprofen and paracetamol can also damage liver function.  Current experiments have found that the anti-inflammatory effects of curcumin are even comparable to some steroid hormones. And so far, people have not found any toxic side effects of curcumin. This undoubtedly paints a very attractive prospect for the role of curcumin in the future anti-inflammatory field.Anti-cancer and anti-cancer effects:Researchers have found that curcumin is effective against many malignant cancer cells, such as breast cancer, pancreatic cancer, ovarian cancer, leukemia cells, and rectal cancer cells with a high incidence. The U.S. National Institutes of Health (NIH) has approved curcumin to begin clinical trials for the treatment of breast, rectal and pancreatic cancers.Anti-oxidize effect:       Antioxidant is a very popular word in recent years. It stems from a theory devised 50 years ago by a man named Harman.He believes that the aging and disease of an organism are due to the excess free radicals produced by the organism in the reaction of aerobic respiration, and if these excess free radicals react with the lipid membrane, DNA, and protein of cells, they can cause Oxidative damage.As a result of this oxidative damage, the normal metabolic function of the organism is unbalanced, the integration ability of the cell itself is lost, the activity of many enzymes is changed, etc., and finally leads to diseases such as cancer, Parkinson's disease, Alzheimer's disease, and various inflammations .One source of the free radicals responsible for these scourges is nitric oxide (NO), which in turn is converted from arginine, an amino acid, by the enzyme nitric oxide synthase (iNOS).In such experiments, curcumin can very effectively inhibit the gene expression of nitric oxide synthase, play a role in reducing the production of nitric oxide in the body, and has a strong antioxidant effect.nervous system protection- Anti-Alzheimer's and Childhood AutismAlzheimer's disease is a disease caused by nerve damage caused by the deposition of a protein called beta-amyloid (β-amyloid) on the brain ganglia to form scar-like things. This amyloid protein is also produced in the brain of normal people, but it is quickly broken down by an enzyme and removed. The activity of this enzyme in the brains of Alzheimer's patients is reduced or even lost, and the amyloid cannot be removed.Curcumin can prevent the accumulation of amyloid protein in the brain by regulating the activity of enzymes and other effects, effectively preventing the deposition of this protein on the ganglia. This discovery undoubtedly opens up a new hope and direction for the treatment of this terrible disease.  Childhood autism (Autism) is an anxiety-provoking and heartbreaking disorder for parents, especially in a society where families can only have one child. The pathogenesis of autism is not very clear at present, there are several hypotheses, including genetics, food factors, heavy metal toxicity, etc., but they have not been confirmed so far. In 2004, researchers at Johns Hopkins University in the United States found that two kinds of immune system-related proteins, Cytokine and Chemokine, were abnormal in the brain tissue of patients with autism. Levels of these two proteins were also found in spinal fluid higher than normal, and both proteins are closely related to the inflammatory response. The evidence suggests a new theory for the cause of autism: that it may be related to certain inflammations that occur in brain tissue.Curcumin has been confirmed to have excellent anti-inflammatory properties, which is why some people are now starting to try it to treat autism in children.

In July 2022, Xixiguangyin Turmeric Probiotic Powder, a high-end probiotic product under Zhejiang Xizhenglin Biotechnology Co., Ltd., was successfully launched on the Qiangguo Mall, which is a platform for learning Qiangguo APP.