Against the backdrop of China’s “Dual‑Carbon” strategy, the National Development and Reform Commission and the National Energy Administration jointly issued the Opinions on Improving Institutional Mechanisms and Policy Measures for the Green and Low‑Carbon Energy Transition (Document No. Fagai Nengyuan〔2022〕206), explicitly supporting the development of bio‑based clean fuels and accelerating the large‑scale deployment of green low‑carbon technologies.China National Petroleum Corporation has also incorporated “Green and Low‑Carbon Development” into its core corporate strategy. According to its 2025 ESG Report, CNPC invested RMB 41.46 billion in new‑energy and new‑material businesses in 2025, representing a 72.4% year‑on‑year increase. Oilfields across the country are accelerating the replacement of chemical agents, hazardous‑waste reduction and harmless treatment of produced water.Amid this wave of industrial transformation, Seedling Bio has achieved the industrial‑scale commercialization of bio‑based rhamnolipid using its proprietary synthetic‑biology platform. The product is widely applicable to oil‑field exploitation, pipeline transportation, environmental protection and other core scenarios, delivering one‑stop green‑transition solutions for oil‑field enterprises that balance production enhancement, operational cost reduction and environmental compliance.Seedling Bio Patent Certificate for Rhamnolipid InventionSeedling Bio holds an invention patent for its proprietary rhamnolipid‑producing strain (Patent No.: ZL202511190286.9), which delivers core technical assurance for consistent product performance.I. Addressing Industry Pain Points: Five Major Dilemmas of Conventional Oilfield DevelopmentFor decades, the petroleum industry has relied on chemical agents to resolve operational challenges. Nevertheless, high costs, heavy pollution and elevated compliance risks have emerged as critical bottlenecks restricting the industry’s green development:1. Rapid production decline in mature oilfields; severe pollution from chemical flooding and high costs for water treatment.2. Low efficiency in heavy‑oil recovery, characterized by high viscosity and substantial energy consumption for lifting.3. Paraffin deposition and corrosion in pipelines, aggravated by secondary pollution from chemical additives.4. Difficult oily‑sludge disposal featuring high costs, safety hazards and low resource‑recovery efficiency.5. Mounting pressure for environmental compliance; risks of excessive chemical residues and regulatory penalties.To tackle these common industrial challenges, Seedling Bio’s bio‑based rhamnolipid leverages the natural advantages of biosurfactants and provides an innovative solution balancing economic and environmental benefits.II. Dispelling the Myth of “Expensive Biological Agents”: Technology‑driven Cost Reduction for Large‑scale ApplicationA widespread misconception within the industry holds that biological agents are costly and impractical for field deployment. Through dual‑track innovation in upstream fermentation technology and downstream application processes, Seedling Bio achieves excellent cost‑performance while guaranteeing product performance and batch‑to‑batch consistency. Its overall application cost outperforms conventional chemical agents:✓ No further purification required: Seedling Bio’s rhamnolipid fermentation supernatant can be directly applied on‑site at oilfields, eliminating high‑cost refining‑purification steps and substantially cutting raw‑material procurement and processing expenses.✓ High‑yield strains for source‑level efficiency and cost optimization: Built upon proprietary high‑yield genetically‑engineered strains paired with precisely‑optimized fermentation protocols, substrate conversion efficiency and volumetric fermentation productivity are greatly improved. Technological advances bring down mass‑production costs while preserving environmental and economic merits.III. Full Coverage of Eight Practical Oil‑field Application ScenariosScenario 1: Heavy‑oil Viscosity Reduction and Enhanced Oil RecoveryTechnical Mechanisms:1. Emulsification (core for production increase): Breaks continuous solid/high‑viscosity residual oil in reservoirs into micron‑sized oil droplets, enabling flow of otherwise immobile crude oil.2. Ultra‑low interfacial tension: Reduces interfacial tension between oil‑droplets, water and rock formations, preventing re‑aggregation of dispersed oil droplets and re‑adsorption of crude oil onto rock surfaces.3. Wettability alteration: Modifies rock‑surface wettability from oil‑wet to water‑wet, drastically lowering crude‑oil adhesion to rock and facilitating removal of residual oil trapped in rock pores.Field‑trial Data:・Binnan Block, Shengli Oilfield: Following field tests with bio‑based flooding agents, the block’s overall daily oil output rose by 18%, substantially unlocking previously‑hard‑to‑produce heavy‑oil reserves.・Large‑scale deployment at Shengli Oilfield: Our self‑developed bio‑composite‑flooding technology has been implemented across 32 well‑groups in 5 major heavy‑oil blocks, achieving cumulative incremental oil production of 39 000 tons during the trial phase.・Xing‑13 Block, Daqing Oilfield: After rhamnolipid‑system injection for merely three months, well‑group daily oil output increased from 16.9 tons to 20.5 tons. All 10 test oil wells delivered higher production, with cumulative incremental oil of 1 893.4 tons for the well‑group.These cases demonstrate that bio‑based rhamnolipid has transitioned from laboratory R&D to industrial‑scale deployment, becoming an indispensable option for oil‑field green transformation and stable‑enhanced production.Scenario 2: Green Biosurfactant Flooding — Replacement for Alkylbenzene SulfonatesAlkylbenzene sulfonates, widely adopted in conventional chemical flooding, present well‑known drawbacks including poor biodegradability, high produced‑water‑treatment costs and potential reservoir‑formation damage. Published studies indicate that rhamnolipid can be compounded with natural bio‑additives such as lecithin to formulate fully bio‑based flooding agents with prominent strengths:・High oil‑displacement efficiency: Core‑flooding laboratory tests achieve 68%‑70% oil‑recovery factor.・Low oil‑water interfacial tension, zero environmental hazards and no extra burden for produced‑water treatment.It serves as a key candidate technology for Green Enhanced Oil Recovery (GEOR).Scenario 3: Integrated Fracturing‑Imbibition for Low‑permeability ReservoirsTo address fast post‑fracture production decline and poor mobilization of residual oil within matrix micro‑pores in tight reservoirs, rhamnolipid can be blended with sulfamic‑acid‑based surfactants and alkalis as an imbibition additive for fracturing‑fluid systems:✓ Reduces capillary resistance, enabling fracturing‑fluid penetration into tight micro‑pores and expanding stimulated reservoir volume.✓ Gradient wettability reversal converts capillary force into driving force for oil displacement.✓ Emulsifies and encapsulates residual oil to boost spontaneous oil‑imbibition capacity of formations.✓ Fully biodegradable, greatly mitigating secondary reservoir‑formation damage.Scenario 4: Full‑range Flow Assurance for Pipeline Transportation Function Rhamnolipid Concentration Performance Heavy‑oil pipeline drag reduction 100~1000 ppm 20%‑50% reduction in pipeline transportation resistance. Crude‑oil viscosity reduction 100~9000 ppm Crude‑oil viscosity reduction ranging from 10% to 90%. Pipeline corrosion inhibition 50 mg/L DBNPA + 500 mg/L rhamnolipid Significantly suppresses microbiologically‑influenced corrosion of X80 pipeline steel induced by SRB. Pipeline blockage removal Regular dosage Emulsifies and strips oily sludge, asphaltenes and paraffin wax, replacing high‑pollution chemical cleaning agents. Scenario 5: Oily‑Sludge / Oil‑Sand TreatmentFeaturing both hydrophilic and lipophilic moieties, rhamnolipid enables efficient oil‑sludge‑water separation via three‑step mechanisms:1. Adsorption: Lipophilic groups selectively adsorb onto crude‑oil molecules on oily‑sludge surfaces.2. Desorption: Weakens adhesion forces between crude‑oil and solid particles, detaching oil films completely from sand‑particle surfaces.3. Emulsification & Dispersion: Encapsulates separated crude‑oil into micron‑sized droplets stably dispersed in the aqueous phase for subsequent recovery.Validated by Published Industry ResearchLaboratory results: Fermentation broth containing rhamnolipid treats diverse oily‑sludge samples, delivering an average oil‑removal rate of 70% within 72 h, and petroleum‑hydrocarbon biodegradation rate reaching 45% over 8‑day incubation.Field‑application data: In one oil‑field pilot, rhamnolipid was used to clean 850 m³ oily sludge, recovering nearly 774 m³ crude‑oil within five days with outstanding resource‑recovery efficiency.Compared with the chemical surfactant SDS: 338 mg/L (10 CMC) rhamnolipid elutes 4106 mg/L crude‑oil, whereas 72 g/L (30 CMC) SDS only achieves 3333.3 mg/L crude‑oil elution. Rhamnolipid provides superior elution efficiency at lower dosage.Scenario 6: Oil‑Gas‑Water SeparationProduced fluids from tight‑oil fracturing exhibit high emulsification stability. Conventional demulsifiers deliver poor performance, leading to excessive water content in exported crude‑oil and heavy downstream produced‑water‑treatment burdens. Published experimental data shows that after rhamnolipid is compounded with conventional polyether‑based chemical demulsifiers:✓ Water‑removal efficiency exceeds 90%, crude‑oil recovery rate surpasses 98%.✓ Water content of recovered oil ＜ 0.3%, suitable for direct refining.✓ Separated aqueous phase is easy‑to‑treat with no secondary pollution.Scenario 7: Offshore Drilling — Eco‑friendly Functional AdditivesTo satisfy environmental‑protection requirements for offshore cementing operations, a bio‑based pre‑flush fluid is formulated with rhamnolipid‑to‑sophorolipid ratio of 2:1. Validated across six core indicators including surface activity, temperature‑salt tolerance, system compatibility, wellbore cleaning, second‑interface bonding performance and gas‑migration prevention, the formulation meets cementing‑engineering specifications while complying with offshore pollutant‑discharge regulations.Scenario 8: Environmental Remediation Soil petroleum‑hydrocarbon remediation Rhamnolipid achieves 63% total petroleum‑hydrocarbon removal rate for heavily‑contaminated soil, outperforming synthetic surfactants such as Triton X‑100 and Tween 80. Heavy‑metal‑contamination remediation Rhamnolipid‑saponin blends generate synergistic effects. At optimal HLB ~10.5, nickel removal reaches 87%, chromium 71%, vanadium 70%, with optimal remediation pH value at 5. Spent‑drilling‑fluid treatment Rhamnolipid and amino‑based high‑adsorption groups are grafted onto β‑cyclodextrin to prepare eco‑friendly adsorbents. The material efficiently sequesters heavy‑metal ions and high‑molecular‑weight organics from spent water‑based drilling fluids and enables harmless disposal via flocculation‑sedimentation, replacing traditional flocculants prone to secondary pollution. Marine oil‑spill remediation Acting as a biodispersant, rhamnolipid promotes emulsification‑dispersion of diesel and other petroleum hydrocarbons and boosts hydrocarbon‑degradation performance of indigenous microbes. The enhancement is most pronounced at 40 mg/L (degradation rate up to 90%). Technical data and figures in this article originate from published literature and industry reports. Actual field performance shall be evaluated against site‑specific operating conditions.About UsSeedling Bio is a leading Chinese synthetic‑biology enterprise focused on R&D, manufacturing and oil‑field‑application solution development for biosurfactants. Leveraging proprietary strain‑engineering technologies and large‑scale fermentation processes, we have developed oil‑field‑grade rhamnolipid products and deliver end‑to‑end technical services for major oilfields ranging from laboratory‑formula optimization to on‑site engineering implementation.Our Core CompetenciesIndustrial‑scale Production Capacity: Large‑scale bio‑fermentation manufacturing base supplies industrial‑grade rhamnolipid fermentation broth or concentrated liquid in stable quality to satisfy large‑volume on‑site deployment.Customized Technology: Custom formula development and application‑engineering design tailored for reservoir geology, crude‑oil properties and process requirements of individual oilfields.Full‑value‑chain Services: One‑stop services including sample supply, laboratory evaluation, on‑site‑test guidance and technical training.Cost‑effective Operations: Proprietary high‑yield genetically‑engineered strains improve fermentation efficiency. Fermentation supernatant can be directly used in oil‑field operations without further refining, cutting costs at both production and application stages.If you are seeking:✅ Green alternatives for heavy‑oil viscosity reduction & enhanced oil recovery✅ Eco‑friendly additives for fracturing fluids in low‑permeability reservoirs✅ Low‑pollution processes for oily‑sludge cleaning & pipeline blockage removal✅ Bio‑based pre‑flush fluids for offshore‑oilfield cementing projectsPlease feel free to contact us via direct message or inquiry! Green low‑carbon oil production represents an irreversible industry trend. Seedling Bio empowers petroleum‑sector green transformation with synthetic‑biology technologies to realize triple benefits: production increase, cost reduction and environmental protection.

Recently, Hydroxytyrosol (standard Chinese name: Dihydroxyphenylethanol), independently‑developed by Zhejiang Seedling Bio‑Technology Co., Ltd., has successfully completed the filing as a new cosmetic raw material (Filing No.: National Cosmetic Raw Material Filing 20260085). This fully demonstrates Seedling Bio’s continuous innovation capacity and leading industry expertise in bioactive ingredients and synthetic‑biology technologies!The successful filing represents authoritative recognition of Seedling Bio’s technical strength and marks a key breakthrough for Seedling Bio in cosmetic‑raw‑material innovation driven by synthetic biology.Leveraging its in‑house synthetic‑biology technology platform, Seedling Bio has established an industrial pathway for de‑novo biosynthesis of hydroxytyrosol from simple carbon sources such as glycerol and glucose. High‑efficiency production of hydroxytyrosol is achieved through metabolic engineering modification and fermentation‑process optimization. Continuous efforts have been made to tackle challenges in separation and purification. The final hydroxytyrosol finished product reaches over 99% purity, featuring light color, high clarity and excellent purity profile. It can be widely incorporated into cosmetic formulations for antioxidant, repairing and soothing purposes, delivering high‑quality ingredients with stable efficacy and full regulatory compliance for the market.Going forward, Seedling Bio will further deepen its footprint in synthetic biology. Taking raw‑material innovation as the core driving force, we will accelerate the translation of scientific achievements into compliant market‑ready products, and keep launching high‑quality, high‑value‑added cosmetic raw materials to facilitate high‑quality development of the industry.Introduction to HydroxytyrosolHydroxytyrosol is a natural polyphenolic antioxidant widely found in leaves, branches and fruits of Olea plants under the Oleaceae family. As an amphiphilic molecule, it possesses favorable liposolubility and water‑solubility together with powerful antioxidant activity. Traditionally, hydroxytyrosol is extracted from olive leaves, olive pomace and olive pressing wastewater. Nevertheless, the average content of hydroxytyrosol in olives is merely 629.1 μg/g, which pushes up extraction costs, and the purity of extracted hydroxytyrosol is generally below 50%.Efficacy BenefitsHydroxytyrosol delivers outstanding antioxidant performance with remarkable ORAC (Oxygen Radical Absorbance Capacity) among polyphenol substances.More than a potent antioxidant and free‑radical scavenger, hydroxytyrosol also exhibits notable soothing and skin‑protective properties, addressing multi‑dimensional skincare demands:・Antioxidant Protection: Effectively scavenge ROS free radicals, defend against photo‑aging and environmental oxidative damage, and delay skin aging;・Repair & Soothing: Alleviate skin redness and discomfort, restore skin barrier function and strengthen skin tolerance;・Improve dull and rough skin, boost skin radiance and refine skin texture.Seedling Bio has completed systematic efficacy verification covering antioxidant, repairing and soothing effects of hydroxytyrosol, and generated complete and authoritative efficacy reports, providing scientific support for diversified application scenarios of the raw material.Safety Profile of HydroxytyrosolToxicological test results demonstrate that hydroxytyrosol features favorable safety performance.High‑purity hydroxytyrosol is suitable for a wide range of high‑end skincare formulations, including:・Anti‑aging Series: Serums, face creams and eye creams to resist oxidative damage and improve fine lines and sagging;・Antioxidant Brightening Series: Brightening serums, overnight rescue masks to fade dull complexion and enhance skin translucency;・Soothing & Repairing Series: Repair creams and barrier‑repair serums for sensitive skin to ease redness and discomfort and restore skin barrier;・Photo‑protection Synergistic Series: Functional synergistic ingredient for sunscreen and after‑sun care products, assisting anti‑photo‑aging and relieving post‑sun redness and dryness.Note: The figure above shows partial commercial products containing hydroxytyrosol for illustration purpose only.About UsSeedling Bio is an innovative enterprise focused on synthetic‑biology technologies. Guided by the development philosophy “Market‑oriented, Technology‑supported, Customer‑centric, Efficiency‑prioritized”, the company leverages synthetic‑biology technologies to independently build the full industrial chain covering strain construction, fermentation & purification, and product application development.At present, the company has realized large‑scale commercial production of multiple food and cosmetic raw materials including Ectoin, S‑Pro‑Xylane, L‑Ergothioneine, Hydroxytyrosol, Salidroside, Sialic Acid, L‑Carnosine, Rhamnolipid and Sophorolipid. Our processes replace conventional production routes such as plant extraction and chemical synthesis and create unique competitive edges. We supply raw‑material products and application support for ingredient distributors, food‑health supplement manufacturers and cosmetic end‑product manufacturers.Core Products: Ectoin, S‑Pro‑Xylane, L‑Ergothioneine, Hydroxytyrosol, Salidroside, Sialic Acid, L‑Carnosine, Rhamnolipid, SophorolipidOther Raw‑Material Products: α‑Arbutin, VC‑Ethyl Ether, Tranexamic Acid, Conotoxin Peptide, NMN, NAD, Inositol, PQQ, Coenzyme Q10, Resveratrol, Glutathione, 1,3‑Dihydroxyacetone, Bisabolol, Pterostilbene, Calcium α‑Ketoglutarate, D‑Panthenol, DL‑Panthenol, Calcium D‑Pantothenate, Niacinamide, Creatine Monohydrate

ISO 9001 is a globally‑recognized quality management system standard that covers full‑process management requirements ranging from product design and manufacturing to delivery and service. The acquisition of this certification demonstrates that Seedling Bio has established an internationally‑aligned standardized management system for the R&D, production, quality control and sales of cosmetic raw materials and health‑food raw materials.Building a Solid Foundation for Quality with International Standards· R&D: Standardized R&D and verification procedures are implemented to ensure controllable R&D workflows and traceable test results.· Production: A full‑chain quality management mechanism covering raw‑material procurement, in‑process production control and finished‑product testing has been optimized to systematically mitigate quality risks across all stages.· Sales: Comprehensive training and assessment programs empower the sales team to deliver prompt responses and professional services so as to meet diversified customer demands.· Service: A closed‑loop service system for quality feedback and technical support is built around customer requirements to continuously improve response efficiency and collaboration performance.ISO 9001 certification is not an end point, but a new starting point for the company to institutionalize and normalize its “Quality First” philosophy.Focusing on Functional Raw Materials, Empowering Health and BeautySeedling Bio focuses on the R&D and innovation of functional cosmetic raw materials and health‑food raw materials. Centered on synthetic‑biology technologies, we are committed to bringing healthier and better life experiences to people.· Core Focus: Functional skincare cosmetic raw materials and health‑functional food raw materials.· R&D Philosophy: Taking synthetic biology as the technical engine and scientific verification as the principle, we guarantee clear efficacy, reliable safety and consistent batch‑to‑batch performance of raw materials.· Service Positioning: Delivering high‑quality, high‑value‑added raw‑material solutions for customers.Taking Certification as a New Starting Point for Higher StandardsThe ISO 9001 certification marks an important milestone in the construction of the company’s quality management system. Building upon this achievement, we will:· Deepen system implementation: Integrate standards into daily operations and safeguard product quality through standardized practices;· Increase R&D investment: Drive development with demand‑oriented innovation;· Strictly observe compliance requirements: Improve safety assessment and full‑process traceability management;· Cooperate with industry partners: Build industry consensus and jointly promote high‑quality and sustainable development of the functional‑raw‑material sector.

■ Green New Power Hidden in Microorganisms — Sophorolipid Seedling Bio has successfully developed microbial fermentation, product separation and purification processes for sophorolipid. Through fermentation‑process optimization, the sophorolipid titer can exceed 250 g/L. The finished product is a pale‑yellow to amber transparent liquid. By adjusting production parameters, sophorolipid products of varying concentrations can be prepared to meet application requirements for diverse scenarios. Production Process: Non‑pathogenic yeast is adopted as the production strain. Using renewable resources such as glucose and vegetable oils as major raw materials, sophorolipid is obtained via fermentation culture, filtration, decolorization and concentration. Compared with complex workflows including polymerization, alkylation, ethoxylation and sulfonation deployed in conventional surfactant manufacturing, Seedling Bio’s sophorolipid production process delivers remarkable advantages in safety, efficiency, environmental friendliness and cost‑effectiveness. ■ Product Introduction ■ Decoding the Structure and Types of Sophorolipid Within the family of biosurfactants, sophorolipid stands out as a high‑performance member. It is mainly produced by Candida yeast species. Its hydrophilic moiety consists of two sophorose molecules, and the hydrophobic segment is a long‑chain hydroxy fatty acid. Dependent on the acetylation degree and position of sugar moieties, as well as fatty‑acid chain length, hydroxylation site and saturation status, dozens to hundreds of structural variants can be generated. Based on the presence or absence of intramolecular esterification, sophorolipids are mainly categorized into acidic type and lactonic type. Lactonic sophorolipid exhibits prominent antibacterial and anti‑tumor activities, while acidic sophorolipid delivers superior solubilizing and foaming capacity together with better antiviral performance. Figure 1 Schematic diagram of molecular structure of sophorolipid ■ Outstanding Performance & Multiple Biological Activities √ Excellent Surface Activity: CMC value ranges from 40‑100 mg/L. A small dosage can sharply lower surface tension (72.8 → 30‑40 mN/m) and improve cleansing and penetrating power. Figure 2 Performance comparison between sophorolipid (SL) and other common surfactants √ Hydrophilic‑Lipophilic Balance (HLB): 10‑13, suitable as emulsifier for oil‑in‑water emulsions. √ Temperature‑resistant and salt‑tolerant √ Non‑toxic, 100% biodegradable √ Mild and non‑irritating to skin Figure 3 Irritation comparison between sophorolipid (SL) and other common surfactants Compared with conventional surfactants widely used in personal‑care products, sophorolipid is milder with lower irritation. √ Anti‑inflammatory & Soothing Effects Figure 4 Inhibitory effect of sophorolipid (SL) at different concentrations on inflammatory factors Sophorolipid can significantly suppress excessive secretion of IL‑6 and TNF‑α induced by lipopolysaccharide and mitigate inflammation. Figure 5 Antihistamine effect of sophorolipid (SL) at different concentrations Pre‑injection of 0.25%‑1% sophorolipid can markedly reduce histamine‑provoked scratching behavior in mice, demonstrating favorable skin‑soothing properties of sophorolipid. √ Antibacterial Activity Figure 6 Growth‑inhibitory effect of sophorolipid at different concentrations against Candida albicans Distinct bactericidal and bacteriolytic effects are observed when sophorolipid concentration exceeds 8.00 mg/mL. ■ Multi‑field Application Scenarios: Unlocking Multiple Identities of Sophorolipid Petroleum & Environmental Protection 1. Enhanced Oil Recovery Sophorolipid serves as an ideal surface‑active component for alkali‑surfactant‑polymer (ASP) flooding systems to boost crude‑oil recovery efficiency. Figure 7 Physical simulation experiment of oil displacement by sophorolipid Figure 8 Oil‑displacement simulation test of compound system composed of sodium carbonate, rhamnolipid and sophorolipid 2. Oil‑Contaminated Sludge Treatment Research shows that treatment with 0.05% sophorolipid achieves 69.57% crude‑oil removal rate for oil‑contaminated sludge. It realizes resource recovery and harmless disposal of oily sludge and prevents hazardous substances from polluting soil and groundwater. Figure 9 Elution performance on oily sludge with sophorolipid of different concentrations Daily‑use Chemicals It covers full‑range scenarios in personal‑care industry. Leveraging its core mild properties, sophorolipid is widely applicable to baby care, sensitive‑skin care, makeup removal & cleansing, oral care, household cleaning and many other fields. For hair care applications, it can not only gently cleanse scalp sebum, but also promote hair growth and improve scalp conditions. It fits well with shampoo and hair‑growth serums, delivering integrated cleansing, care and nourishment. Figure 10 Hair‑regeneration promoting effect of sophorolipid Agriculture Bacteriostasis & Fresh‑keeping: Sophorolipid presents favorable inhibitory effects on common pathogenic and spoilage microorganisms. It can be used as a novel fungicide for crop cultivation and as preservative for fruits and vegetables. For instance, apples coated with 3.0 mg/mL sophorolipid still retain glossy peel after 9‑day storage. Figure 11 Fresh‑keeping effect of sophorolipid on apples (A: blank control; B: apple coated with 3.0 mg/mL sophorolipid) A multi‑functional treasure ingredient, sophorolipid represents the perfect combination of nature and modern biotechnology, embodying scientific concepts of healthy lifestyle, environmental protection and sustainable development. Within the vast surfactant market, sophorolipid stands as one of the most promising alternatives to conventional surfactants thanks to its outstanding performance. According to relevant reports, the global sophorolipid market is projected to reach approximately USD 1.5 billion in 2025 and grow to around USD 2.0 billion by 2030, with a compound annual growth rate (CAGR) of about 6.5%. China’s market growth is particularly remarkable: China’s sophorolipid market size is expected to expand from USD 350 million in 2025 to USD 550 million by 2030, lifting its global market share from 23% to 27.5%. Going forward, Seedling Bio will develop multi‑dimensional, diversified and customized products and solutions centered on sophorolipid to facilitate its broader deployment across multiple industries. 

Recently, the Office of the National Leading Group for the Administration of High‑tech Enterprise Accreditation released the filing list of high‑tech enterprises accredited in Zhejiang Province in 2025. With outstanding technological innovation capabilities, a sound R&D system and fruitful scientific and technological transformation achievements, Seedling Bio has successfully passed the national high‑tech enterprise accreditation. This honor is not only high recognition of Seedling Bio’s innovation strength, R&D proficiency and industrial value in the biotechnology sector, but also a landmark achievement in the company’s development history, injecting brand‑new impetus into its high‑quality development.As an enterprise focusing on innovative development in the biotechnology field, Seedling Bio has taken technological innovation as its core driving force for development since its establishment. It delves deep into core biotechnology R&D tracks and consolidates the foundation for corporate growth.The company owns a 1000 m³ R&D center equipped with a complete range of laboratory equipment including PCR instruments, electroporators, electrophoresis apparatuses, gel imaging systems, ultra‑low‑temperature freezers, clean benches, 5‑50 L fermentation systems, ceramic‑membrane and organic‑membrane separation systems, high‑performance liquid chromatographs and stability test chambers. Such hardware meets full‑process development requirements covering strain construction and modification, fermentation‑purification process development and verification, finished‑product testing and application development. Led by a Young Yangtze River Scholar of the Ministry of Education, the R&D team covers molecular biology, fermentation, purification and testing. Most members are graduates from top‑tier universities at home and abroad, over 60% of whom hold postgraduate degrees. Possessing profound expertise in synthetic biology, the team can rapidly complete independent R&D and iterative upgrading of synthetic biological products.✅ High‑quality R&D Team: We have built an R&D team led by senior industry experts, doctors and masters, set up a high‑standard biotechnology innovation platform and continuously increased R&D investment to provide solid support for innovation‑driven development.✅ Standardized R&D System: A full‑process management system from laboratory R&D to industrial application has been established to ensure efficient implementation of technological innovation as well as rapid and accurate achievement transformation.✅ Core Intellectual Property Reserves: We have accumulated multiple core technologies through independent research and development, filed more than 20 patent applications in total and obtained 13 granted patents, building solid technical barriers in the field of biosynthesis.Seedling Bio has widely applied synthetic biology technologies to health supplements, functional foods, novel cosmetic raw materials and other fields. It steadily promotes the industrialization of synthetic biology so that innovative technologies can serve the general health industry in real earnest.Since its foundation, Seedling Bio has obtained seven authoritative qualifications and honors including Zhejiang Provincial Science‑ and‑Technology‑oriented Small‑ and‑Medium‑sized Enterprise and Hangzhou Municipal Enterprise High‑tech R&D Center. Every honor serves as motivation for us to forge ahead.Moving forward, Seedling Bio will uphold its corporate mission “Green Technology Creates a Brighter Future”. We will strengthen technological innovation capacity, R&D‑production capacity and management capacity to enhance the company’s core competitiveness. Seedling Bio strives to become a leader in the synthetic biology industry, leveraging synthetic biology technologies to better serve the nutrition and general‑health sector and generate greater value!In recent years, relying on its self‑developed core technology platforms, the company has made major breakthroughs in cosmetic, food and health‑supplement raw materials, and realized R&D and large‑scale production of multiple innovative products. With leading technical strengths and industrialization capabilities, we have delivered high‑quality, high‑value‑added raw‑material solutions for global customers. Our core featured products are as follows:   Ectoin, Ergothioneine, Pro‑Xylane, α‑Arbutin, Sialic Acid, Carnosine, Hydroxytyrosol, Sophorolipid, Rhamnolipid  New Cosmetic Raw MaterialsD‑Panthenol     DL‑Panthenol     NiacinamideVC‑Ethyl Ether     Creatine Monohydrate     Calcium D‑PantothenateHexanediol     Pentylene GlycolOther ProductsDHA   CA‑AKG   Salidroside   PQQ   NAD+Coenzyme Q10   Resveratrol   NMN   Pterostilbene   Tranexamic AcidInositol   Carnosine   Glutathione   L‑Dopa   Bisabolol

In the first half of this year,Raw material products independently developed by Seedling BiotechPatents related to Ectoine (also known as tetrahydro-pyrimidine) and boswellin"Construction method and application of a genetically engineered bacterium producing tetrahydro pyrimidine""Method and engineered bacteria for preparing (β,S) configuration bosin through enzyme catalysis"They passed the examination conducted by the State Intellectual Property Office in April and June respectively,was granted the patent right for invention.The acquisition of two invention patent certificates,It not only marks the official recognition of Seedling Biotechnology's innovative technological capabilities,It also further contributes to the company's intellectual property system,Protect the core technology of raw material products.Invention patent certificate for Ectoine and BosinRaw material product - EctoineEctoine (INCI name: tetrahydroxymethyl pyrimidine carboxylic acid) is a small-molecule amino acid derivative. It appears as white crystals or powder, and its molecular structure carries a carboxyl group and a cyclic amino group, which can form a strong electrostatic potential. This potential structures the free water within cells. Through its powerful water molecule complexing ability, it forms a hydration layer around biomolecules, protecting the structure and function of cells and biological macromolecules.In cosmetics, ectoine is often used as a skin conditioning agent, which can enhance skin's water-locking ability, provide long-lasting moisturization, alleviate damage and inflammation caused by external irritants such as dry environments, surfactants, and ultraviolet radiation, and strengthen the repair and immune capabilities of skin cells.With the continuous deepening of research on ectoine, it has also been discovered that ectoine has the effect of enhancing crop stress resistance, promoting crop growth, and strengthening crop resistance to pests and diseases in the agricultural field. Ectoine is expected to play a significant role in the improvement of saline-alkali soil, coping with extreme climate, and the transformation towards green agriculture.Through thorough research and meticulous design of the biosynthetic pathway of ectoine, Xi Zhenglin has constructed engineered bacterial strains capable of efficiently synthesizing ectoine and completed the upgrade of mass production processes. Leveraging the independently developed biosynthetic technology of ectoine, he has significantly expanded the range of available raw materials and significantly reduced the production cost of ectoine.Raw material product - BosinBoswellin (INCI Chinese name: hydroxypropyl tetrahydroxypyrantriol) is a functional ingredient commonly used in cosmetics. It can promote the synthesis of glycosaminoglycans in the human dermis, enhance the production of proteoglycans, and stimulate the regeneration of collagen. Glycosaminoglycans, proteoglycans, and collagen are all crucial structural components of the extracellular matrix, playing a pivotal role in maintaining the skin's firmness, uniformity, smoothness, and elasticity, as well as preserving its healthy state.The external manifestations of skin aging include skin thinning, skin sagging, loss of elasticity, and deepening wrinkles. In research on skin aging, it has been found that both naturally aged skin and photo-aged skin exhibit varying levels of decline in glycosaminoglycans and proteoglycans. The use of cosmetics containing boswellin can promote epidermal renewal, strengthen skin structure, firm the skin, improve wrinkles, increase skin radiance and elasticity. Therefore, boswellin is known as one of the "three anti-aging giants" in the skin care industry and is widely used in face creams, serums, and other products from prestigious brands.Boswellin is a β-xylose derivative with multiple chiral carbon atoms in its molecular structure. The spatial arrangement of chiral carbon atoms on its parent core is relatively fixed, while the carbon atom at position 7 in the aglycone (hydroxypropane) gives rise to two different configurations, namely (β,S) and (β,R), which are diastereoisomers. Studies have shown that the biological activity of the (β,S) configuration is superior to that of the (β,R) configuration, and the cytotoxicity of the (β,S) configuration is weaker than that of the (β,R) configuration.Boswellin is a β-xylose derivative with multiple chiral carbon atoms in its molecular structure. The spatial arrangement of chiral carbon atoms on its parent core is relatively fixed, while the carbon atom at position 7 in the aglycone (hydroxypropane) gives rise to two different configurations, namely (β,S) and (β,R), which are diastereoisomers. Studies have shown that the biological activity of the (β,S) configuration is superior to that of the (β,R) configuration, and the cytotoxicity of the (β,S) configuration is weaker than that of the (β,R) configuration.The biosynthetic technology of bosein developed by Seedling Bio utilizes specific biological enzyme catalysis, with acetone xyloside as the main raw material. It boasts advantages such as high substrate conversion rate and high product purity (purity of (β,S) bosein > 99%), and effectively achieves continuous production through immobilized enzyme technology.The raw materials of Seedling Biotech, namely Ectoine and Boswellin, have currently obtained multiple third-party certifications such as safety assessment, quality inspection, and efficacy testing. With the innovative strength represented by patent certificates, they will provide strong endorsement for our customers in terminal product development and market application. As an innovative enterprise specializing in synthetic biology technology, Seedling Biotech will continue to delve deeper in future development, realizing the vision of creating a better life with green technology.Safety assessment report on Ectoine and Boswellin raw materials  Quality test report of Ectoine and Boselium  Efficacy Test Report of Ectoine and BoswellinCore biological raw material productsIn recent years, relying on our self-developed core technology platform, our company has achieved significant breakthroughs in the fields of cosmetics, food, and health care product ingredients, successfully developing and mass-producing multiple innovative products. Leveraging our leading technological advantages and industrialization capabilities, we have provided high-quality, high-value-added ingredient solutions to customers worldwide. The following are our core featured products:Currently, these raw material products have been applied to the supply chains of over 20 leading enterprises across various industries, marking the maturity of the company's full-chain capabilities from "research and development to production and sales".Contact our Mr. Luo at 13588347582