Recently, Hydroxytyrosol (standard Chinese name: Dihydroxyphenylethanol), independently‑developed by Zhejiang Seedling Bio‑Technology Co., Ltd., has successfully completed the filing as a new cosmetic raw material (Filing No.: National Cosmetic Raw Material Filing 20260085). This fully demonstrates Seedling Bio’s continuous innovation capacity and leading industry expertise in bioactive ingredients and synthetic‑biology technologies!
The successful filing represents authoritative recognition of Seedling Bio’s technical strength and marks a key breakthrough for Seedling Bio in cosmetic‑raw‑material innovation driven by synthetic biology.
Leveraging its in‑house synthetic‑biology technology platform, Seedling Bio has established an industrial pathway for de‑novo biosynthesis of hydroxytyrosol from simple carbon sources such as glycerol and glucose. High‑efficiency production of hydroxytyrosol is achieved through metabolic engineering modification and fermentation‑process optimization. Continuous efforts have been made to tackle challenges in separation and purification. The final hydroxytyrosol finished product reaches over 99% purity, featuring light color, high clarity and excellent purity profile. It can be widely incorporated into cosmetic formulations for antioxidant, repairing and soothing purposes, delivering high‑quality ingredients with stable efficacy and full regulatory compliance for the market.
Going forward, Seedling Bio will further deepen its footprint in synthetic biology. Taking raw‑material innovation as the core driving force, we will accelerate the translation of scientific achievements into compliant market‑ready products, and keep launching high‑quality, high‑value‑added cosmetic raw materials to facilitate high‑quality development of the industry.
Introduction to Hydroxytyrosol
Hydroxytyrosol is a natural polyphenolic antioxidant widely found in leaves, branches and fruits of Olea plants under the Oleaceae family. As an amphiphilic molecule, it possesses favorable liposolubility and water‑solubility together with powerful antioxidant activity. Traditionally, hydroxytyrosol is extracted from olive leaves, olive pomace and olive pressing wastewater. Nevertheless, the average content of hydroxytyrosol in olives is merely 629.1 μg/g, which pushes up extraction costs, and the purity of extracted hydroxytyrosol is generally below 50%.
Efficacy Benefits
Hydroxytyrosol delivers outstanding antioxidant performance with remarkable ORAC (Oxygen Radical Absorbance Capacity) among polyphenol substances.
More than a potent antioxidant and free‑radical scavenger, hydroxytyrosol also exhibits notable soothing and skin‑protective properties, addressing multi‑dimensional skincare demands:
・Antioxidant Protection: Effectively scavenge ROS free radicals, defend against photo‑aging and environmental oxidative damage, and delay skin aging;
・Repair & Soothing: Alleviate skin redness and discomfort, restore skin barrier function and strengthen skin tolerance;
・Improve dull and rough skin, boost skin radiance and refine skin texture.
Seedling Bio has completed systematic efficacy verification covering antioxidant, repairing and soothing effects of hydroxytyrosol, and generated complete and authoritative efficacy reports, providing scientific support for diversified application scenarios of the raw material.
Safety Profile of Hydroxytyrosol
Toxicological test results demonstrate that hydroxytyrosol features favorable safety performance.
High‑purity hydroxytyrosol is suitable for a wide range of high‑end skincare formulations, including:
・Anti‑aging Series: Serums, face creams and eye creams to resist oxidative damage and improve fine lines and sagging;
・Antioxidant Brightening Series: Brightening serums, overnight rescue masks to fade dull complexion and enhance skin translucency;
・Soothing & Repairing Series: Repair creams and barrier‑repair serums for sensitive skin to ease redness and discomfort and restore skin barrier;
・Photo‑protection Synergistic Series: Functional synergistic ingredient for sunscreen and after‑sun care products, assisting anti‑photo‑aging and relieving post‑sun redness and dryness.
Note: The figure above shows partial commercial products containing hydroxytyrosol for illustration purpose only.
About Us
Seedling Bio is an innovative enterprise focused on synthetic‑biology technologies. Guided by the development philosophy “Market‑oriented, Technology‑supported, Customer‑centric, Efficiency‑prioritized”, the company leverages synthetic‑biology technologies to independently build the full industrial chain covering strain construction, fermentation & purification, and product application development.
At present, the company has realized large‑scale commercial production of multiple food and cosmetic raw materials including Ectoin, S‑Pro‑Xylane, L‑Ergothioneine, Hydroxytyrosol, Salidroside, Sialic Acid, L‑Carnosine, Rhamnolipid and Sophorolipid. Our processes replace conventional production routes such as plant extraction and chemical synthesis and create unique competitive edges. We supply raw‑material products and application support for ingredient distributors, food‑health supplement manufacturers and cosmetic end‑product manufacturers.
Core Products: Ectoin, S‑Pro‑Xylane, L‑Ergothioneine, Hydroxytyrosol, Salidroside, Sialic Acid, L‑Carnosine, Rhamnolipid, Sophorolipid
Other Raw‑Material Products: α‑Arbutin, VC‑Ethyl Ether, Tranexamic Acid, Conotoxin Peptide, NMN, NAD, Inositol, PQQ, Coenzyme Q10, Resveratrol, Glutathione, 1,3‑Dihydroxyacetone, Bisabolol, Pterostilbene, Calcium α‑Ketoglutarate, D‑Panthenol, DL‑Panthenol, Calcium D‑Pantothenate, Niacinamide, Creatine Monohydrate
